National Perinatal Information Center
National Perinatal Information Center


CLINICALLY RELATED STUDIES


Corticosteroid Dissemination Study
As part of the Agency for Health Care Policy Research's Low Birthweight PORT the University of Alabama studied the dissemination of Corticosteroids. NPIC subcontracted to collaborate on the data collection and analysis of the change in the use rates of corticosteroids. The design called for the enrollment of 20 NPIC member hospitals, 10 of whom agreed to participate in an educational effort for physicians aimed at promoting steroid use according to the NIH consensus conference guidelines.
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Implications of Surfactant for Mortality, Morbidity and Cost in Neonatal Intensive Care
This study was funded by the National Heart Lung and Blood Institute, and it assessed the impact of surfactant on mortality, morbidity and resource use on neonates 500 to 1,500 grams. The analysis used the NPIC Perinatal Center Data Base which contains clinical and financial data on all neonates admitted to fourteen member hospitals for six years (1985-1990). After the exclusion of multiple gestation, outborn infants, all infants in clinical trial years, 5,629 inborn singleton neonates remained in the analysis. Infants were then divided into a pre and post period based upon the date surfactant was approved for market use by the FDA.
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Implications of Surfactant for Mortality, Morbidity and Cost in Neonatal Intensive Care Phase II
"Implications of Surfactant for Mortality, Morbidity and Cost in Neonatal Intensive Care Phase II" was funded by the National Heart Lung and Blood Institute to expand on the original study which assessed the impact of surfactant on mortality, morbidity and resource use on neonates 500 to 1,500 grams. The Phase II component added additional years to the study and focused on exploring the nature of IVH and BPD morbidity in survivors. The Phase II analytic activities used the NPIC Perinatal Center Data Base which contains clinical and financial data on all neonates admitted to fourteen member hospitals for seven and a half years (1985-1992). After the exclusion of multiple gestation, outborn infants, all infants in clinical trial years, 7358 inborn singleton neonates remained in the analysis. Infants were then divided into a pre and post period based upon the date surfactant was approved for market use by the FDA.
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